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Erosive toe-web intertrigo: Clinical features and management.

N Jacob1, O Rousseau2, V Guardiolle3

  • 1Dermatology Department, CHU de Nantes, Hôtel Dieu, 1 Place Alexis-Ricordeau, 44093 Nantes, France.

Annales De Dermatologie Et De Venereologie
|July 24, 2024
PubMed
Summary

Gram-negative bacterial toe-web intertrigo (GNB-TW) is challenging to treat. Standardized topical corticosteroid (TCS) treatment showed efficacy but did not significantly reduce disease duration compared to non-standardized approaches.

Keywords:
FootGram-negative bacteriaIntertrigoToe web

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Pharmacology

Background:

  • Gram-negative bacterial toe-web intertrigo (GNB-TW) presents as painful, weeping lesions, often recurrent and debilitating.
  • Associated eczema and poorly codified management contribute to treatment challenges.

Purpose of the Study:

  • To evaluate the efficacy and safety of a standardized treatment plan using topical corticosteroids (TCS).
  • To assess the impact of standardized treatment on disease course and recurrence frequency in GNB-TW.

Main Methods:

  • Prospective interventional study comparing standardized TCS treatment with a retrospective cohort using non-standardized management.
  • Data collected on disease duration, recurrence, and associated factors over a 6-month period.

Main Results:

  • No significant difference in median disease duration between standardized (61 days) and non-standardized (56 days) treatment groups.
  • Relapses were more frequent in the non-standardized group (21.4%) compared to the standardized group (7.7%).
  • Pseudomonas aeruginosa was the predominant pathogen (48.1%); eczema was associated in 51.8% of cases.

Conclusions:

  • Topical corticosteroids (TCS) are effective and well-tolerated for GNB-TW intertrigo.
  • Standardized treatment did not reduce disease duration but may decrease relapse frequency.
  • GNB-TW intertrigo remains a difficult-to-treat condition, often linked with eczema.