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Ganospirones A-G, seven undescribed spiro-meroterpenoids from Ganoderma lucidum and their biological activities
Dan Li1, Sheng-Hong Li2, Qiang Gao2
1School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, People's Republic of China.
Abstract:
Ganoderma lucidum, a medicinal mushroom with a long history in traditional Chinese medicine, is widely used for chronic diseases. Ganospirones A-G (1-7), seven pairs of undescribed spiro-meroterpenoids, were isolated from the fruiting bodies of G. lucidum. Their structures including absolute configurations were characterized by using NMR spectroscopic data, ECD computational and X-ray diffraction methods. The anti-inflammatory and anti-renal fibrosis activities of the meroterpenoids 1-7 were tested, and the results revealed that (-)-2 and (+)-2 could inhibit iNOS expression in lipopolysaccharide-induced RAW264.7 cells at 20 μM.
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