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Parasite Induced Genetically Driven Autoimmune Chagas Heart Disease in the Chicken Model
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Association between positive serology for COVID-19 and chagas cardiomyopathy progression: The SaMi-Trop project

Ariela Mota Ferreira1, Léa Campos Oliveira-da Silva2, Clareci Silva Cardoso3

  • 1Department of Infectious and Parasitic Diseases, University of São Paulo, São Paulo, SP, Brazil; Postgraduate Program in Health Sciences, State University of Montes Claros, Montes Claros, MG, Brazil.

Travel Medicine and Infectious Disease
|July 24, 2024
PubMed

Insights

COVID-19 infection is linked to the worsening of Chagas cardiomyopathy. This study found that Chagas disease patients with COVID-19 showed accelerated cardiac progression over one year.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Chagas disease (CD) can lead to Chagas cardiomyopathy.
  • COVID-19 also impacts the cardiovascular system and may exacerbate existing conditions.
  • The cardiac effects of COVID-19 on CD patients are not well understood.

Purpose of the Study:

  • To evaluate cardiac progression in Chagas disease patients one year after COVID-19 infection.
  • To determine if COVID-19 influences the natural course of Chagas cardiomyopathy.

Main Methods:

  • A longitudinal study tracked Chagas disease patients over one year.
  • Cardiac progression was defined by new major electrocardiogram (ECG) changes.
  • COVID-19 infection status (positive serology) was the primary independent variable.

Main Results:

  • 22.8% of 404 participants had positive COVID-19 serology; 10.9% showed cardiac progression.
  • COVID-19 positivity was significantly associated with cardiac progression (OR=2.65).
  • In patients with normal baseline ECGs, COVID-19 was linked to new-onset cardiomyopathy (OR=3.50).

Conclusions:

  • COVID-19 infection is associated with the progression of Chagas cardiomyopathy.
  • The findings suggest that COVID-19 may accelerate the natural progression of Chagas disease.
  • Repeated ECG evaluations are crucial for monitoring cardiac changes in CD patients post-COVID-19.
Abstract

Keywords:
COVID-19Chagas diseaseDisease progression

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