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Infection and Branhamella catarrhalis
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|January 1, 1985
Summary
Neisseria catarrhalis, often overlooked as a pathogen, is increasingly causing infections. Rising beta-lactamase production in these bacteria impacts antibiotic treatment choices, particularly for ampicillin.
Area of Science:
- Microbiology
- Infectious Diseases
- Bacteriology
Background:
- Neisseria meningitidis and Neisseria (Branhamella) catarrhalis are Gram-negative cocci found in the nasopharynx.
- B. catarrhalis is traditionally considered a commensal, leading to under-reporting of its pathogenic role.
- There is growing awareness of B. catarrhalis's pathogenic potential, especially with increasing beta-lactamase producing strains.
Purpose of the Study:
- To highlight the under-recognized pathogenic role of Neisseria catarrhalis.
- To emphasize the clinical significance of beta-lactamase production in B. catarrhalis.
- To inform about the implications for antibiotic therapy.
Main Methods:
- Literature review and synthesis of existing data on Neisseria (Branhamella) catarrhalis.
- Analysis of reports on pathogenic status and antibiotic resistance.
- Focus on beta-lactamase production trends.
Main Results:
- Neisseria catarrhalis is increasingly recognized as a pathogen.
- A significant rise in beta-lactamase producing strains of B. catarrhalis is reported globally.
- Ampicillin resistance is a growing concern due to beta-lactamase production.
Conclusions:
- Neisseria catarrhalis warrants greater attention as a potential pathogen.
- The increasing incidence of beta-lactamase production necessitates reassessment of antibiotic treatment strategies.
- Ampicillin may no longer be a reliable treatment option for infections caused by B. catarrhalis.