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Updated: Jul 20, 2026

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An Ex vivo Model to Study Hormone Action in the Human Breast
Published on: January 8, 2015
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Applying Artificial Intelligence Constructing a Prediction Model Related to Environmental Hormones and Breast Cancer
Chih-Yen Chang1,2, Pei-Hung Liao2
1General Surgery, Cheng Hsin General Hospital, Taipei, Taiwan.
Studies in Health Technology and Informatics
|July 25, 2024
Summary
Environmental hormones are linked to increased breast cancer risk. This study identified heavy metals and chemicals like phthalate metabolites as key risk factors, prompting further investigation into daily habits and environmental exposures.
Area of Science:
- Environmental Science
- Oncology
- Toxicology
Background:
- Breast cancer is a leading global cause of mortality, with a concerning trend of younger diagnoses.
- Environmental factors, particularly endocrine-disrupting chemicals, are increasingly implicated in cancer development.
Purpose of the Study:
- To develop a predictive model for breast cancer incidence based on environmental hormone exposure.
- To identify specific environmental risk factors associated with breast cancer.
Main Methods:
- Analysis of laboratory data to identify potential risk factors.
- Statistical methods including Chi-square, Neural Network, and Logistic Regression were employed.
- Planned verification of identified risk factors through patient habit surveys.
Main Results:
- Lead, Copper, Zinc, Mercury, Chromium, Chloramphenicol, Sulfonamides, and Penicillin were identified as potential risk factors.
- Specific phthalate metabolites, Monethyl phthalate (MEP) and Monobenzyl phthalate (MBHP), showed a relationship with breast cancer incidence.
- These findings highlight a correlation between environmental contaminants and breast cancer risk.
Conclusions:
- Environmental hormones and specific chemical exposures are significantly associated with breast cancer incidence.
- Further research and public awareness are crucial to mitigate risks associated with environmental hormone exposure.
- The study establishes a foundation for understanding the link between environmental factors and breast cancer.

