The effect of RNLS gene polymorphisms on preeclampsia susceptibility: a meta-analysis study

Area of Science:

• Genetics
• Obstetrics
• Molecular Biology

Background:

• Preeclampsia (PE) is a serious pregnancy complication.
• Genetic factors are implicated in PE susceptibility.
• The role of RNLS gene polymorphisms in PE requires further investigation.

Purpose of the Study:

• To conduct a meta-analysis evaluating the association between RNLS gene polymorphisms and preeclampsia risk.
• To comprehensively assess the impact of specific RNLS variants on PE susceptibility.

Main Methods:

• Systematic literature search of PubMed, Scopus, and Google Scholar databases.
• Meta-analysis performed using STATA (ver. 12.0) and MetaGenyo web tool.
• Analysis of RNLS rs10887800 and rs2576178 polymorphisms in relation to PE.

Main Results:

• The RNLS rs10887800 polymorphism was associated with an increased risk of PE across allelic, heterozygous codominant, and dominant genetic models.
• The RNLS rs2576178 polymorphism demonstrated a higher risk of PE in allelic, homozygous codominant, dominant, and recessive genetic models.
• Both studied RNLS polymorphisms showed a significant association with preeclampsia susceptibility.

Conclusions:

• The RNLS rs10887800 and rs2576178 polymorphisms are potential genetic risk factors for preeclampsia.
• These findings contribute to understanding the genetic basis of preeclampsia.
• Further research may explore the functional mechanisms underlying these associations.