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Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: May 10, 2026

Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging

Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging

Published on: April 14, 2011

Tumor-Induced Osteomalacia: A Case Report.

Dayanidhi Meher¹, Ranjana Giri², Vishal Agarwal¹

¹Endocrinology, Diabetes and Metabolism, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.

|July 26, 2024

Summary

Tumor-induced osteomalacia (TIO) is a rare condition causing bone pain and fractures due to a tumor. Early diagnosis and surgical removal of the tumor effectively treat TIO, restoring normal phosphorus levels.

Area of Science:

Endocrinology
Oncology
Nephrology

Background:

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by hypophosphatemia and osteomalacia.
TIO often presents with vague symptoms like bone pain, potentially delaying diagnosis.

Keywords:

fibroblast growth factor-23 oncogenic osteomalacia phosphaturia symptomatic hypophosphatemia tumor-induced osteomalacia

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