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Cardiovascular Diseases Increase Cancer Mortality in Adults: NHANES-Continuous Study.
Omar M Makram1,2, Tochukwu Okwuosa3, Daniel Addison4
1Department of Medicine Medical College of Georgia at Augusta University Augusta GA USA.
Journal of the American Heart Association
|July 26, 2024
Summary
Cardiovascular disease (CVD) increases cancer mortality risk. Obesity exacerbates this risk, highlighting the need to manage shared risk factors for better health outcomes.
Area of Science:
- Epidemiology
- Public Health
- Oncology
Background:
- Cancer and cardiovascular disease (CVD) are leading global causes of death.
- Limited evidence exists on the relationship between CVD, its risk factors, and cancer mortality.
Purpose of the Study:
- To investigate the association between cardiovascular disease (CVD) and cancer mortality.
- To examine the role of cardiovascular risk factors in cancer mortality.
Main Methods:
- Prospective cohort study using NHANES (National Health and Nutrition Examination Survey), Medicare, and National Death Index data (1999-2018).
- Included 44,591 adults without prior cancer history, analyzing CVD as primary exposure and risk factors as secondary.
- Employed competing risk modeling to assess cancer mortality outcomes.
Main Results:
- Individuals with CVD exhibited a significantly higher risk of cancer mortality (aHR, 1.37).
- Cancer mortality risk increased with age, current smoking, and obesity.
- A significant interaction revealed higher cancer mortality in individuals with both CVD and obesity (aHR, 1.73).
Conclusions:
- A strong link exists between cardiovascular health and cancer mortality.
- Obesity significantly contributes to cancer mortality in individuals with CVD.
- Proactive management of shared risk factors for CVD and cancer is crucial.
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