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Regional Differences in Hepatitis C-Related Hospitalization Rates, United States, 2012-2019.

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Summary
This summary is machine-generated.

Hepatitis C virus (HCV) hospitalizations decreased nationwide from 2012-2019, but regional differences persist. Expanding access to direct-acting antiviral treatments can further reduce hospitalizations and transmission.

Keywords:
National Inpatient Samplehealth care utilizationhepatitis Chospitalizationregional differences

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Area of Science:

  • Public Health
  • Infectious Diseases
  • Hepatology

Background:

  • Hepatitis C is a leading cause of liver cancer and death in the US.
  • It imposes a significant burden on hospitalizations.
  • Understanding regional disparities is crucial for hepatitis C elimination efforts.

Purpose of the Study:

  • To analyze regional variations in hepatitis C virus (HCV)-related hospitalizations in the US from 2012 to 2019.
  • To inform strategies for hepatitis C elimination.

Main Methods:

  • Analysis of National Inpatient Sample discharge data from 2012-2019.
  • HCV-related hospitalizations defined by primary or secondary diagnosis.
  • Modeling of annual percentage change in HCV-related hospitalization rates by US Census Bureau geographic divisions.

Main Results:

  • An estimated 553,900 HCV-related hospitalizations occurred in the US between 2012-2019.
  • The West South Central region had the highest hospitalization rate (34.7 per 100,000), while West North Central had the lowest (17.6 per 100,000).
  • Annual hospitalization rates declined across all regions, with the Pacific region showing the largest decrease (48.8%). Medicaid was the predominant insurance type for hospitalizations.

Conclusions:

  • HCV-related hospitalizations decreased nationally and regionally between 2012-2019, but the decline was uneven.
  • Unequal access to direct-acting antiviral treatments may contribute to disparities.
  • Expanding access to early-stage HCV treatment is recommended to reduce future hospitalizations and transmission.