Related Experiment Video
Updated: May 6, 2026
A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
Validation of a Simplified Laboratory-Based HCV Clearance Definition Using New York City Hepatitis C Program and
Christina S Hwang1, Martha P Montgomery, Diana I Diaz Munoz
1Author Affiliations: Bureau of Hepatitis, HIV and STI, New York City Department of Health and Mental Hygiene, New York City, New York (Mss Hwang, Diaz Munoz, and Bocour); and National Center for HIV, Viral Hepatitis, STD, and TB Prevention at US Centers for Disease Control and Prevention, Atlanta, Georgia (Drs Montgomery, Yin, and Teshale).
Context:
Laboratory-based hepatitis C virus (HCV) clearance cascades are an important tool for health departments to track progress toward HCV elimination, but a laboratory-based definition of HCV clearance has not yet been validated.
Objective:
To compare agreement between a laboratory-based HCV clearance definition with a clinical cure definition.
Design:
Observational.
Setting:
New York City Department of Health and Mental Hygiene HCV surveillance system data and New York City hepatitis C linkage-to-care program data.
Participants:
Linkage-to-care program participants who were diagnosed with hepatitis C and enrolled in the linkage-to-care program from July 1, 2016, through June 30, 2020.
Main Outcome Measure:
Percent agreement between a laboratory-based HCV clearance definition (surveillance system) and a clinical cure definition (program data).
Results:
Among 591 program participants with known treatment outcome, the laboratory-based HCV clearance definition and clinical cure definition were concordant in 573 cases (97%).
Conclusions:
A laboratory-based HCV clearance definition based on public health surveillance data can be a reliable source for monitoring HCV elimination.
