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Innovative Approach to Accelerate Wound Healing: Synthesis and Validation of Enzymatically Cross-Linked COL-rGO
Luisbel González1, Víctor Espinoza1, Mauricio Tapia1
1Laboratorio de Biomateriales, Departamento de Ingeniería Química, Facultad de Ingeniería, Universidad de Concepción, Concepción 4030000, Chile.
Gels (Basel, Switzerland)
|July 26, 2024
Summary
This study developed a new collagen and reduced graphene oxide biomaterial for wound dressings. The conductive hydrogel enhanced wound healing and fluid absorption, showing significant potential for medical applications.
Area of Science:
- Biomaterials Science
- Materials Chemistry
- Regenerative Medicine
Background:
- Advanced wound dressings are crucial for effective healing.
- Developing conductive and absorbent biomaterials is a key challenge.
Purpose of the Study:
- To synthesize and characterize a novel conductive hybrid biomaterial for wound dressing applications.
- To evaluate the material's properties, including conductivity, stability, and absorption capacity.
- To assess its efficacy in promoting wound closure.
Main Methods:
- Synthesis of collagen (COL) and reduced graphene oxide (rGO) hybrid hydrogels.
- Plasticization with glycerol and enzymatic cross-linking with horseradish peroxidase (HRP).
- Characterization using FTIR, XRD, XPS, and assessment of biodegradation, absorption, and in vitro wound closure.
- Dopamine polymerization for enhanced stability.
Main Results:
- Successful synthesis and interaction of COL and rGO components confirmed.
- Increased rGO concentration enhanced conductivity and negative charge density.
- Improved hydrogel stability, reduced biodegradation, and enhanced resistance to collagenase type I.
- High absorption capacity (215 g/g) and significant in vitro wound closure rate (84.5% at 48 h).
Conclusions:
- The developed COL/rGO hybrid biomaterial exhibits promising properties for wound healing.
- The material's conductivity, stability, and absorption capacity contribute to accelerated wound closure.
- This innovative composite biomaterial presents a viable option for advanced wound dressing applications.
