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Updated: Jun 19, 2025

Optogenetic Activation of Intrinsic Cardiac Autonomic Neurons in Excised Perfused Mouse Hearts
Published on: March 28, 2025
Optogenetic modulation of cardiac autonomic nervous system
Ramon A Hernández-Domínguez1, Jorge F Herrera-Orozco2, Guadalupe E Salazar-Calderón3
1Electrocardiology Department, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1 Belisario Domínguez secc. 16 Tlalpan CP 14080, Mexico City, Mexico; Surgery Department, Hospital Regional de Alta Especialidad Dr. Juan Graham Casasús, Calle Uno S/N, Miguel Hidalgo III Etapa, Villahermosa, 86126, Tabasco, Mexico.
Abstract:
The following is a narrative review of the fundamentals of optogenetics. It focuses on the advantages and constraints of manipulating the autonomic nervous system by modifying the pathophysiological characteristics that arise in different diseases. Although the use of this technique is currently experimental, we will discuss improvements that have been implemented and identify the necessary measures for potential preclinical translation in the control of the cardiac autonomic nervous system.
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