Related Experiment Video
Updated: Jun 19, 2025

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
Published on: December 2, 2022
Association Between Uveal Melanoma and Allostatic Load
Haarisudhan Sureshkumar1, Abhijith Eathara1, Avisek Datta2
1Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, Chicago, IL, U.S.A.
Allostatic load (AL), a measure of chronic stress, was significantly associated with extraocular extension in uveal melanoma (UM) patients. Further research is needed to explore this link and other clinical features.
Area of Science:
- Oncology
- Immunology
- Stress Physiology
Background:
- Allostatic load (AL) quantifies chronic stress.
- Chronic stress negatively impacts cancer outcomes.
- Uveal melanoma (UM) is a rare intraocular malignancy.
Purpose of the Study:
- To investigate the association between allostatic load (AL) and clinical features of uveal melanoma (UM).
- To determine if chronic stress markers correlate with tumor characteristics in UM patients.
Main Methods:
- Retrospective cohort study of 111 UM patients.
- AL score calculated using ten biomarkers.
- Linear and logistic regression analyses performed.
Main Results:
- Significant association found between high AL score and extraocular extension (p=0.015).
- Mean blood glucose levels differed significantly across tumor size groups (p=0.029).
- A trend suggested higher AL scores with smaller tumor sizes (p=0.069).
Conclusions:
- AL score is significantly linked to extraocular extension in UM.
- Smallest UM tumors correlated with highest blood glucose.
- Further investigation into AL and extraocular extension is warranted.
- Socioeconomic factors' role in chronic stress and UM requires study.
More Related Videos
12:37Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
13:26Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
Published on: August 11, 2016
Related Concept Videos
Psychoneuroimmunology: Diabetes and Cancer
Glaucoma: Overview
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Photoreceptors and Visual Pathways
Changes in Skin Color: Clinical Perspectives
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...