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Updated: Jun 19, 2025

Fluorescence-based Measurement of Store-operated Calcium Entry in Live Cells: from Cultured Cancer Cell to Skeletal Muscle Fiber
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Extended Synaptotagmins 1 and 2 Are Required for Store-Operated Calcium Entry, Cell Migration and Viability in Breast

Pedro C Redondo1, Jose J Lopez1, Sandra Alvarado1

  • 1Department of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, Spain.

Cancers
|July 27, 2024
PubMed
Summary

Extended synaptotagmins (E-Syts) are proteins involved in store-operated calcium entry (SOCE) in breast cancer. E-Syt1 and E-Syt2 overexpression in breast cancer cells correlates with enhanced SOCE, cell migration, and viability.

Keywords:
E-Syt1E-Syt2SOCEcell migrationcell viability

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