Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Olfaction01:25

Olfaction

40.5K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
40.5K
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

10.5K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
10.5K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

13.1K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
13.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The 'active reciprocity' ecosystem: senior cohousing as a determinant of social support and cognitive vitality independent of socioeconomic status.

Frontiers in public health·2026
Same author

Cognitive Performance Among Older Adults with Subjective Cognitive Decline.

Geriatrics (Basel, Switzerland)·2025
Same author

Olfactory Identification as a Biomarker for Cognitive Impairment: Insights from Healthy Aging, Subjective Cognitive Decline, and Mild Cognitive Impairment.

European journal of investigation in health, psychology and education·2024
Same author

Association of a DASH diet and magnetoencephalography in dementia-free adults with different risk levels of Alzheimer's disease.

GeroScience·2024
Same author

APOE genotype, hippocampal volume, and cognitive reserve predict improvement by cognitive training in older adults without dementia: a randomized controlled trial.

Cognitive processing·2024
Same author

The efficacy of olfactory training in improving olfactory function: a meta-analysis.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2024

Related Experiment Video

Updated: May 1, 2026

Olfactory Assays for Mouse Models of Neurodegenerative Disease
07:27

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Published on: August 25, 2014

22.0K

Maximizing Participation in Olfactory Training in a Sample with Post-COVID-19 Olfactory Loss.

Alice Helena Delgado-Lima1, Jaime Bouhaben1, María Luisa Delgado-Losada1

  • 1Experimental Psychology, Cognitive Processes and Speech Therapy Department, Faculty of Psychology, Complutense University of Madrid, 28223 Pozuelo de Alarcón, Spain.

Brain Sciences
|July 27, 2024
PubMed
Summary

This study demonstrates that online olfactory training is feasible for COVID-19 patients, with significant improvements in smell function. The program achieved 100% adherence, offering a new approach for olfactory rehabilitation.

Keywords:
COVID-19olfactory dysfunctionolfactory rehabilitationolfactory trainingtherapeutic approach

More Related Videos

Simple and Computer-assisted Olfactory Testing for Mice
06:40

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

10.0K
Olfactory Context Dependent Memory: Direct Presentation of Odorants
04:47

Olfactory Context Dependent Memory: Direct Presentation of Odorants

Published on: September 18, 2018

6.5K

Related Experiment Videos

Last Updated: May 1, 2026

Olfactory Assays for Mouse Models of Neurodegenerative Disease
07:27

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Published on: August 25, 2014

22.0K
Simple and Computer-assisted Olfactory Testing for Mice
06:40

Simple and Computer-assisted Olfactory Testing for Mice

Published on: June 15, 2015

10.0K
Olfactory Context Dependent Memory: Direct Presentation of Odorants
04:47

Olfactory Context Dependent Memory: Direct Presentation of Odorants

Published on: September 18, 2018

6.5K

Area of Science:

  • Otolaryngology
  • Neurology
  • Infectious Diseases

Background:

  • Olfactory dysfunction is a common and persistent symptom following COVID-19 infection.
  • Olfactory training (OT) is a recognized treatment for olfactory loss.
  • Remote delivery of healthcare interventions is increasingly important.

Purpose of the Study:

  • To assess the feasibility of a fully online olfactory training program for patients with post-COVID-19 olfactory dysfunction.
  • To evaluate the effectiveness of this remote OT program on olfactory function recovery.

Main Methods:

  • 11 participants with post-COVID-19 olfactory loss underwent a 12-week classic olfactory training program.
  • Weekly video calls were used to ensure adherence and collect data on olfactory perception.
  • Olfactory status was compared to a control group of COVID-19 patients without olfactory loss and a healthy control group.

Main Results:

  • The experimental group showed statistically significant improvements in olfactory function (TDI score) from baseline to week 12 and week 24.
  • 100% of participants completed the online olfactory training program, indicating high adherence.
  • While improved, the post-COVID-19 olfactory loss group still scored lower than controls, suggesting potential long-term effects.

Conclusions:

  • An online-monitored olfactory training program is a feasible and effective intervention for patients with post-COVID-19 olfactory dysfunction.
  • The high adherence rate suggests that remote delivery models are well-suited for olfactory rehabilitation.
  • This approach provides a scalable framework for future olfactory training studies and patient care.