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Polymeric Microneedle Array Fabrication by Photolithography
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Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Bioactive Release.

Manoj B Sharma1,2, Hend A M Abdelmohsen2,3, Özlem Kap4

  • 1Department of Chemistry, Lancaster University, Lancaster LA1 4YB, UK.

Bioengineering (Basel, Switzerland)
|July 27, 2024
PubMed
Summary
This summary is machine-generated.

Poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel microneedles effectively deliver bioactive molecules like estradiol, melatonin, and meropenem transdermally. These robust microneedles show potential for treating various conditions through minimally invasive drug delivery.

Keywords:
drug deliveryestradiolhydrogelsmelatoninmeropenemmicroneedles

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Microneedle arrays are minimally invasive devices for transdermal and intradermal drug delivery.
  • Hydrogel-based microneedles offer potential for controlled release of bioactive molecules.
  • Poly(2-hydroxyethyl methacrylate) (pHEMA) is a versatile hydrogel material for biomedical applications.

Purpose of the Study:

  • To demonstrate the release of bioactive molecules from pHEMA hydrogel microneedle patches in vitro.
  • To evaluate the mechanical properties of pHEMA microneedles for tissue penetration.
  • To analyze the release kinetics of bioactives from the microneedle system.

Main Methods:

  • Fabrication of pHEMA hydrogel microneedle patches.
  • In vitro release studies of estradiol, melatonin, and meropenem.
  • Mechanical testing of microneedles using phantom tissues.
  • Mathematical modeling of drug release kinetics (zero-order, first-order, second-order).

Main Results:

  • pHEMA microneedles exhibited sufficient mechanical strength for soft tissue penetration.
  • Successful in vitro release of estradiol, melatonin, and meropenem was demonstrated.
  • Bioactive release profiles were successfully fitted to established kinetic models.

Conclusions:

  • pHEMA hydrogel microneedles are a viable platform for transdermal delivery of diverse bioactives.
  • The mechanical robustness and controlled release capabilities support their potential clinical application.
  • This technology holds promise for minimally invasive treatment of various medical conditions.