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CX-5461 Preferentially Induces Top2α-Dependent DNA Breaks at Ribosomal DNA Loci

Donald P Cameron1,2, Jirawas Sornkom2,3, Sameerh Alsahafi4

  • 1ACRF Department of Cancer Biology and Therapeutics, Division of Genome Sciences and Cancer, The John Curtin School of Medical Research, The College of Health and Medicine, The Australian National University, Canberra, ACT 2601, Australia.

Biomedicines
|July 27, 2024
PubMed

Keywords:
CX-5461DNA damage pathwayRNA Polymerase Idouble-strand breaksnucleolar surveillance pathwayp53ribosome biogenesistopoisomerase

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