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Updates on the Renin-Angiotensin-Aldosterone System and the Cardiovascular Continuum
Dana Pop1,2, Alexandra Dădârlat-Pop1,3, Raluca Tomoaia1,2
14th Department of Internal Medicine, Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.
Biomedicines
|July 27, 2024
Summary
The renin-angiotensin-aldosterone system impacts the cardiovascular continuum from risk factors to heart failure. Targeting its components may help halt disease progression.
Area of Science:
- Cardiovascular Medicine
- Endocrinology
- Pharmacology
Background:
- The cardiovascular continuum links risk factors to severe outcomes like heart failure.
- The renin-angiotensin-aldosterone system (RAAS) is implicated across all continuum stages.
- RAAS dysregulation contributes to atherothrombosis, ischemic heart disease, and renal failure.
Purpose of the Study:
- To analyze the role of RAAS components in the cardiovascular continuum's pathophysiology.
- To explore potential therapeutic targets within the RAAS for disease progression arrest.
Main Methods:
- Review of existing literature on RAAS and cardiovascular disease.
- Analysis of the mechanisms linking RAAS components to atherothrombosis and heart failure.
- Examination of aldosterone, angiotensin, and their receptors' involvement.
Main Results:
- RAAS components are central to initiating and advancing cardiovascular disease.
- Specific enzymes, angiotensin types, receptors, and aldosterone drive pathological processes.
- These factors contribute significantly to atherosclerosis and cardiac remodeling.
Conclusions:
- The RAAS is a critical mediator throughout the cardiovascular continuum.
- Targeting specific RAAS elements offers a promising strategy to interrupt disease progression.
- Further research into RAAS modulation is warranted for cardiovascular and renal protection.
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