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The Role and Function of TRPM8 in the Digestive System
Zunan Wu1,2, Shuai Peng1,2, Wensha Huang1,2
1Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Transient receptor potential melastatin member 8 (TRPM8) channels are involved in digestive system functions and diseases. This review details TRPM8
Area of Science:
- Physiology
- Molecular Biology
- Gastroenterology
Background:
- Transient receptor potential melastatin member 8 (TRPM8) is a thermosensitive ion channel activated by cold and chemical stimuli.
- TRPM8 is expressed in various tissues, including the digestive system, where it plays roles in physiological and pathological processes.
Purpose of the Study:
- To comprehensively review the distinct roles of TRPM8 in different digestive organs.
- To provide insights for future mechanistic investigations and identify potential therapeutic targets for TRPM8-related digestive diseases.
Main Methods:
- Literature review of studies investigating TRPM8 expression and function in the digestive system.
- Analysis of TRPM8's involvement in esophageal, gastric, colorectal, hepatic, and pancreatic functions and pathologies.
Main Results:
- TRPM8 is implicated in diverse digestive system functions and pathologies, including inflammation, tumors, and sensory/functional disorders.
- Specific roles of TRPM8 vary across different digestive organs, highlighting tissue-specific functions.
Conclusions:
- TRPM8 is a significant player in digestive system physiology and pathology.
- Further research into TRPM8 mechanisms can lead to novel therapeutic strategies for digestive diseases.
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