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Updated: Jun 19, 2025
12:19
Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks
Published on: November 10, 2016
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Structure and Functions of HMGB3 Protein
Elena Chikhirzhina1, Anna Tsimokha1, Alexey N Tomilin1
1Institute of Cytology of the Russian Academy of Sciences, Tikhoretsky Av. 4, 194064 St. Petersburg, Russia.
International Journal of Molecular Sciences
|July 27, 2024
Summary
High-mobility group box 3 (HMGB3) protein, crucial for DNA processes and immune responses, is gaining research attention. This review covers HMGB3 structure, function, and its role in tumor development via degradation.
Area of Science:
- Molecular Biology
- Cellular Biology
- Biochemistry
Background:
- High-mobility group box (HMGB) proteins are nuclear proteins involved in DNA dynamics.
- HMGB1 and HMGB2 functions are well-established, but HMGB3 remains understudied.
- HMGB proteins participate in DNA repair, replication, transcription, and immune responses.
Purpose of the Study:
- To review current knowledge on HMGB3.
- To summarize HMGB3's molecular structure and post-translational modifications.
- To explore HMGB3's biological functions and its role in tumorigenesis.
Main Methods:
- Literature review of existing studies on HMGB3.
- Analysis of data on HMGB3 molecular structure and modifications.
- Investigation of HMGB3's involvement in cellular processes and disease.
Main Results:
- HMGB3 shares core HMGB protein functions in DNA processes.
- HMGB3 exhibits distinct post-translational modifications influencing its activity.
- HMGB3 degradation via the ubiquitin-proteasome system may impact tumor development.
Conclusions:
- HMGB3 is an important protein with diverse cellular roles.
- Further research into HMGB3 is warranted, particularly its role in cancer.
- Understanding HMGB3 degradation pathways could offer therapeutic insights.
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