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Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination with Anticancer Drugs on C6 Rat Glioma Model

Gulim K Mukusheva¹, Roza I Jalmakhanbetova², Altynay Zh Shaibek¹

¹Faculty of Chemistry, Karaganda Buketov University, Karaganda 100024, Kazakhstan.

Molecules (Basel, Switzerland)

|July 27, 2024

Abstract:

Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor activity, in combination with the commonly used five anticancer drugs, namely cyclophosphane, fluorouracil, etoposide, cisplatin, ribomustine with different mechanisms of action, was investigated. Based on the quantum chemical calculations data and molecular docking, hypotheses have been put forward to explain their mutual influence when affecting C6 rat glioma model cells.

Keywords:

anabasine antiproliferative activity cytisine cytotoxic activity drug synergism isoxazole molecular docking quantum chemical modeling ureas

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