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Conjugated Proteins

Conjugated Proteins

Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...

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Updated: Jun 18, 2025

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

A "Plug-And-Display" Nanoparticle Vaccine Platform Based on Outer Membrane Vesicles Displaying SARS-CoV-2 Receptor-Binding Domain

Published on: July 25, 2022

Functionally Designed Nanovaccines against SARS-CoV-2 and Its Variants.

Yue Xi¹, Rongrong Ma^1,2, Shuo Li^1,2

¹State Key Laboratory of Stress Biology and Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China.

|July 27, 2024

Summary

Nanovaccines offer a promising alternative to traditional vaccines for preventing COVID-19 (caused by SARS-CoV-2). This review explores nanoparticle vaccine vectors, their advantages, and recent advancements for developing innovative antiviral vaccines.

Keywords:

SARS-CoV-2 functionalization nanovaccines

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Published on: August 21, 2019

Area of Science:

Immunology
Nanotechnology
Virology

Background:

The COVID-19 pandemic, caused by SARS-CoV-2, has severely impacted global healthcare systems.
There is a critical need for effective vaccine development strategies.
Conventional vaccine platforms face limitations, necessitating novel approaches.

Purpose of the Study:

To review widely used nanoparticle vaccine vectors for SARS-CoV-2 prevention.
To outline the benefits and drawbacks of different nanovaccine approaches.
To examine recent advancements in nanovaccine technology for antiviral applications.

Main Methods:

Literature review of nanoparticle vaccine vectors.
Analysis of benefits and drawbacks of nanovaccine platforms.
Examination of recent developments in nanovaccine research for SARS-CoV-2.

Main Results:

Nanovaccines present a distinct opportunity to advance vaccine research.
Advantages include enhanced host immune response and multivalent antigen delivery.
Nanoparticle platforms offer efficient drug delivery capabilities.

Conclusions:

Nanovaccines provide a convenient and effective alternative to conventional vaccines.
Further development of nanovaccines is crucial for innovative antiviral vaccine design.
This review serves as a reference for future nanovaccine development against SARS-CoV-2 and other viruses.