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Summary
A single 2g intramuscular dose of cefotetan effectively treated lower urinary tract infections in six of seven women. Most patients remained infection-free for four weeks, with mild side effects reported.
Area of Science:
- Infectious Diseases
- Pharmacology
- Urology
Background:
- Lower urinary tract infections (LUTIs) are common, particularly in women.
- Antibiotic resistance necessitates evaluating effective treatment options for LUTIs.
Purpose of the Study:
- To assess the efficacy and safety of a single intramuscular dose of cefotetan for treating LUTIs in female patients.
Main Methods:
- Seven female patients diagnosed with LUTIs were enrolled.
- Treatment involved a single 2g intramuscular injection of cefotetan.
- Clinical cure was assessed at 1 week and maintained at 4 weeks post-treatment.
Main Results:
- Six out of seven patients (85.7%) achieved clinical cure at 1 week.
- Five of the seven patients (71.4%) remained symptom-free at 4 weeks.
- One patient experienced loose stools and a rash; another had injection site soreness and induration. No other adverse events were noted.
Conclusions:
- A single intramuscular dose of cefotetan demonstrates high clinical efficacy for treating LUTIs in women.
- The treatment is generally well-tolerated, with a low incidence of mild side effects.
- Cefotetan represents a potentially valuable therapeutic option for managing female LUTIs.