Related Experiment Video
Updated: Jun 18, 2025

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
Published on: August 25, 2023
Neuroendocrine Neoplasms
Sukhjeet Kamboj1, Francis Guerra-Bauman1, Hussain Mahmud2
1Department of Family Medicine, WellSpan Good Samaritan Hospital Family Medicine Residency Program, PO Box 1520, Lebanon, PA 17042, USA.
Neuroendocrine neoplasms (NENs), or neuroendocrine tumors (NETs), are rare, diverse tumors. This article reviews their types, presentations, diagnosis, and management strategies for better patient care.
Area of Science:
- Oncology
- Endocrinology
- Pathology
Background:
- Neuroendocrine neoplasms (NENs), also known as neuroendocrine tumors (NETs), originate from cells with neuroendocrine properties.
- These rare tumors exhibit significant heterogeneity in clinical behavior and biology.
Purpose of the Study:
- To provide a comprehensive overview of neuroendocrine neoplasms (NENs).
- To detail the varied clinical presentations, diagnostic approaches, and management strategies for common NENs.
Main Methods:
- Literature review of NENs.
- Synthesis of information on tumor types, clinical syndromes, diagnostic methods, and treatment modalities.
Main Results:
- NENs present diversely based on type, location, hormonal activity, grade, and metastatic status.
- Management requires a multidisciplinary approach tailored to individual patient and tumor characteristics.
Conclusions:
- Understanding the heterogeneity of NENs is crucial for accurate diagnosis and effective treatment.
- This review offers a guide to the clinical management of common neuroendocrine neoplasms.
More Related Videos
08:57Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
Published on: May 17, 2024
12:04Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
Published on: August 14, 2012
Related Concept Videos
Neural Regulation
Structures of the Endocrine System
Classification of Neurotransmitters
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Adrenergic Neurons: Neurotransmission
Synthesis: Catecholamine synthesis requires tyrosine, which...
Enzyme-linked Receptors
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...