Refinement of Risk-Stratification of Cytogenetically Normal Acute Myeloid Leukemia Adult Patients by MN1 Expression

Area of Science:

• Hematology
• Oncology
• Molecular Biology

Background:

• Acute myeloid leukemia with normal cytogenetics (CN-AML) is genetically diverse.
• Identifying prognostic markers is crucial for managing CN-AML patients.
• The prognostic role of MN1 expression in adult CN-AML was investigated.

Purpose of the Study:

• To evaluate the prognostic significance of MN1 gene expression in adult CN-AML.
• To correlate MN1 expression levels with clinical characteristics and patient outcomes.

Main Methods:

• MN1 expression was quantified using real-time PCR in 163 de-novo adult AML patients.
• Correlations between MN1 expression, clinical features, and survival outcomes were analyzed.

Main Results:

• Higher MN1 expression correlated with NPM1 wild-type, CD34 positivity, and lower remission rates.
• High MN1 expression was significantly associated with poor event-free survival (EFS) and overall survival (OS).
• Multivariate analysis confirmed MN1 copy number as an independent predictor of EFS and OS.

Conclusions:

• MN1 expression serves as an independent prognostic indicator in CN-AML.
• Elevated MN1 levels are linked to adverse outcomes in this patient group.
• This study underscores the importance of MN1 as a predictive biomarker for CN-AML.