Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-time polymorphic form assessment of pharmaceuticals at tabletting pressures using micro-scale quantities.

International journal of pharmaceutics·2025
Same author

Correction: LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis.

Cell death & disease·2025
Same author

Semi-crystalline materials for pharmaceutical fused filament fabrication: Dissolution and porosity.

International journal of pharmaceutics·2024
Same author

[A case of metastatic breast cancer complicated by pulmonary tumor thrombotic microangiopathy].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2023
Same author

Development and implementation of a pneumatic micro-feeder for poorly-flowing solid pharmaceutical materials.

International journal of pharmaceutics·2023
Same author

PERPETRATION OF VIOLENCE BY FEMALE SEX WORKERS IN PAPUA NEW GUINEA: 'WE WILL CRUSH THEIR BONES'.

The British journal of criminology·2022

Related Experiment Video

Updated: Jul 10, 2026

High Throughput Single-cell and Multiple-cell Micro-encapsulation
16:19

High Throughput Single-cell and Multiple-cell Micro-encapsulation

Published on: June 15, 2012

18.7K

A continuous micro-feeder for cohesive pharmaceutical materials.

P Hou1, M O Besenhard2, G Halbert1

  • 1Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G1 1XQ, UK; Centre for Continuous Manufacturing and Advanced Crystallisation (CMAC), University of Strathclyde, Glasgow G1 1RD, UK.

International Journal of Pharmaceutics
|July 28, 2024
PubMed
Summary
This summary is machine-generated.

A novel micro-feeder effectively addresses pharmaceutical continuous manufacturing challenges by consistently feeding poorly flowing powders at low rates (<20 g/h). This versatile solution operates without feedback control, ensuring accuracy for cohesive and non-flowing materials.

Keywords:
Continuous feedingDouble-screw agitatorLow dose feedingPowder micro-feedingScrew feeder

More Related Videos

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

22.0K
Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses
09:43

Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses

Published on: March 8, 2024

1.6K

Related Experiment Videos

Last Updated: Jul 10, 2026

High Throughput Single-cell and Multiple-cell Micro-encapsulation
16:19

High Throughput Single-cell and Multiple-cell Micro-encapsulation

Published on: June 15, 2012

18.7K
Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

22.0K
Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses
09:43

Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses

Published on: March 8, 2024

1.6K

Area of Science:

  • Pharmaceutical Manufacturing
  • Chemical Engineering
  • Materials Science

Background:

  • Continuous manufacturing is gaining traction in the pharmaceutical sector.
  • Challenges persist in powder blending and feeding operations, particularly at low throughputs.
  • Consistent feeding of solid drug substances and excipients at low rates is a significant hurdle.

Purpose of the Study:

  • To demonstrate a micro-feeder system for continuous and consistent feeding of poorly flowing pharmaceutical powders.
  • To evaluate the micro-feeder's performance with various powder types at low feed rates.
  • To assess the system's reliability and versatility for pharmaceutical applications.

Main Methods:

  • Investigated a micro-feeder system designed for low feed rate powder delivery.
  • Tested the system with three pharmaceutical powders: croscarmellose sodium (cohesive), magnesium stearate (very cohesive), and paracetamol (non-flowing).
  • Analyzed feeding consistency and variability at flow rates below 20 g/h.

Main Results:

  • The micro-feeder achieved continuous and consistent powder feeding at low rates (<20 g/h).
  • Low variability was observed: <10% for non-flowing and <5% for cohesive materials.
  • The system operated effectively without feedback control and was unaffected by refilling.

Conclusions:

  • The developed micro-feeder successfully overcomes the challenge of accurate and consistent powder feeding at low rates.
  • The system's robust performance makes it a versatile and industry-relevant solution for pharmaceutical continuous manufacturing.
  • This technology offers a significant advancement for unit operations requiring precise low-throughput powder handling.