Related Experiment Video

Updated: May 10, 2026

Non-invasive Assessment of Microvascular and Endothelial Function
05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

16.2K

Angio-microRNAs in diabetic foot ulcer-: Mechanistic insights and clinical perspectives

Mohammad Hasan Soheilifar1, Nastaran Masoudi-Khoram2, Mahmoud Hassani3

  • 1Department of Medical Laser, Medical Laser Research Center, Yara Institute, ACECR, Tehran, Iran.

Progress in Biophysics and Molecular Biology
|July 28, 2024
PubMed

Insights

Diabetic foot ulcers impair wound healing, particularly angiogenesis, due to microRNA (miRNA) imbalances. AngiomiRs show promise as biomarkers and therapeutic targets for promoting blood vessel growth in chronic wounds.

Area of Science:

  • Biomedical Science
  • Molecular Biology
  • Wound Healing Research

Background:

  • Diabetic foot ulcers (DFUs) represent a growing global health challenge, significantly impacting wound healing.
  • Impaired angiogenesis is a key factor in the chronicity of DFUs.
  • MicroRNAs (miRNAs) dysregulation disrupts the balance of angiogenic factors, contributing to poor wound repair.

Purpose of the Study:

  • To review the role of angiogenesis in chronic wound healing.
  • To investigate the mechanisms of pro- and anti-angiomiRs in diabetic foot ulcer pathogenesis.
  • To explore the potential of angiomiRs as biomarkers and therapeutic agents.

Main Methods:

  • Literature review focusing on angiogenesis, miRNAs, and diabetic foot ulcers.
  • Analysis of mechanisms involving pro-angiogenic and anti-angiogenic miRNAs.
  • Exploration of biomarker and therapeutic potential of angiomiRs.

Main Results:

  • Aberrant miRNA expression is implicated in the angiogenesis dysfunction observed in DFUs.
  • AngiomiRs can modulate the balance of angiogenic factors, influencing wound healing.
  • Specific angiomiRs present potential as diagnostic biomarkers for chronic wounds.

Conclusions:

  • Dysregulated angiomiRs play a critical role in the impaired angiogenesis of diabetic foot ulcers.
  • Targeting angiomiRs offers a promising therapeutic strategy to promote angiogenesis and enhance wound healing.
  • Further research into angiomiRs could lead to novel treatments for chronic wounds.
Keywords:
AngiogenesisDiabetic foot ulcerWound healingmiRNA

More Related Videos

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

2.8K
Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations08:21

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

1.3K

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...