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Novel Atomic Force Microscopy Based Biopanning for Isolation of Morphology Specific Reagents against TDP-43 Variants in Amyotrophic Lateral Sclerosis

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Published on: February 12, 2015

EVolution in ALS diagnosis: molecular markers in extracellular vesicles

Philippe Codron¹, Stéphanie Millecamps², Philippe Corcia³

¹Centre de Référence sur la SLA d'Angers, Centre Hospitalier Universitaire d'Angers, Angers, France; Laboratoire de Neurobiologie et Neuropathologie, Centre Hospitalier Universitaire d'Angers, Angers, France; University of Angers, Inserm, CNRS, MITOVASC, SFR ICAT, Angers, France.

Trends in Molecular Medicine

|July 28, 2024

Abstract

None:

The identification of biomarkers for amyotrophic lateral sclerosis (ALS) is a central issue in disease research. In a recent article, Chatterjee et al. show that blood extracellular vesicles (EVs) with high levels of transactive response DNA-binding protein 43 (TDP-43) accurately discriminate patients with ALS from controls and correlate with disease severity, providing a promising biomarker for early diagnosis and monitoring.

Keywords:

TDP-43 amyotrophic lateral sclerosis biomarker cryptic exons extracellular vesicles

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