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After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
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Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
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Protocol for Human Blastoids Modeling Blastocyst Development and Implantation
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Accelerating the paradigm shift in Blastocystis research.

Jeff Tomiak1, Christen Rune Stensvold2

  • 1University of Stavanger, Department of Chemistry, Bioscience, and Environmental Engineering, Stavanger, Norway; Laboratory of Parasitology, Department of Bacteria, Parasites, and Fungi, Statens Serum Institut, Copenhagen, Denmark.

Trends in Parasitology
|July 28, 2024
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Summary
This summary is machine-generated.

Blastocystis, once considered a parasite, may actually benefit gut health. Its presence correlates with increased microbial diversity and better cardiometabolic health, suggesting a symbiotic role.

Keywords:
biomarkersdisease predictioneukaryomegut healthgut microbiomemetagenomics

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Area of Science:

  • Microbiology
  • Human Health
  • Gut Microbiome Research

Background:

  • Blastocystis is a common, yet controversial, single-celled microorganism residing in the human gut.
  • Historically viewed as an intestinal pathogen, recent research suggests a potential shift in understanding its role.

Purpose of the Study:

  • To investigate the association between Blastocystis colonization and indicators of gut health.
  • To explore the relationship between Blastocystis and cardiometabolic health markers.
  • To re-evaluate the symbiotic potential of Blastocystis in the human gut ecosystem.

Main Methods:

  • Analysis of human gut microbiome data.
  • Correlation studies linking Blastocystis presence with gut health parameters.
  • Assessment of cardiometabolic risk factors in relation to Blastocystis colonization.

Main Results:

  • Blastocystis presence was linked to improved gut health.
  • Higher microbial diversity was observed in individuals colonized with Blastocystis.
  • Favorable cardiometabolic outcomes were associated with Blastocystis colonization.

Conclusions:

  • Blastocystis may play a beneficial role in the gut microbiome.
  • The organism's presence could indicate a healthy gut environment and diet.
  • Blastocystis warrants further investigation as a potential gut symbiont rather than a pathogen.