Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastrulation01:56

Gastrulation

57.0K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
57.0K
Development of Blood Vessels01:07

Development of Blood Vessels

555
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
555
Morphogenesis02:19

Morphogenesis

27.8K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
27.8K
Development of the Sexual Organs in the Embryo and Fetus01:15

Development of the Sexual Organs in the Embryo and Fetus

621
Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
621
Cleavage and Blastulation01:33

Cleavage and Blastulation

45.0K
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
45.0K
Cellular Differentiation00:57

Cellular Differentiation

2.6K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assembly of Microtubule Tactoids Through Condensates of PRC1 Constructs.

Biomolecules·2026
Same author

A Predictive Model for Coupling Cell Division Orientation to Tissue Mechanics During Epithelial Morphogenesis.

bioRxiv : the preprint server for biology·2026
Same author

Mitotically Driven Cytoskeletal Reorganization Governs Zebrafish Left-Right Organizer Detachment from EVL and Lumen Morphogenesis.

bioRxiv : the preprint server for biology·2026
Same author

Insights into the zebrafish left-right organizer's centrosomes and cilia via volume electron microscopy.

Biology open·2026
Same author

Functionally Essential and Structurally Diverse: Insights into the zebrafish Left-Right Organizer's Cilia via Optogenetic IFT88 Perturbation and Volume Electron Microscopy.

bioRxiv : the preprint server for biology·2025
Same author

Dynamic forces drive cell and organ morphology changes during embryonic development.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same journal

Layered social competition coordinates reproductive hierarchy formation in ants.

bioRxiv : the preprint server for biology·2026
Same journal

Combination epigenetic-targeted therapy increases the immunogenicity of poorly immunogenic sarcomas.

bioRxiv : the preprint server for biology·2026
Same journal

Loss of LanC-like proteins delays post-injury regeneration of aging skeletal muscles.

bioRxiv : the preprint server for biology·2026
Same journal

Integrative Transfer Network: Deep Transfer Learning Across Populations and Prediction Targets.

bioRxiv : the preprint server for biology·2026
Same journal

Confidence-supported label-free metabolic imaging with FPhaS phase autofluorescence microscopy.

bioRxiv : the preprint server for biology·2026
Same journal

Sequence-encoded autoinhibition couples mRNA decapping activity to phase separation.

bioRxiv : the preprint server for biology·2026
See all related articles

Related Experiment Video

Updated: Jun 18, 2025

Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis
06:33

Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis

Published on: June 5, 2018

7.3K

Dynamical forces drive cell and organ morphology changes during embryonic development.

Raj Kumar Manna1,2,3, Emma M Retzlaff4, Anna Maria Hinman4

  • 1Department of Physics Syracuse University, Syracuse, NY 13244, USA.

Biorxiv : the Preprint Server for Biology
|July 29, 2024
PubMed
Summary
This summary is machine-generated.

Dynamic forces from tissue movements shape organs during embryonic development. Experiments in zebrafish embryos confirm that these forces, not just biochemical signals, are crucial for organ morphology.

More Related Videos

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo
08:19

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Published on: October 17, 2011

12.9K
Probing Cell Mechanics with Bead-Free Optical Tweezers in the Drosophila Embryo
08:23

Probing Cell Mechanics with Bead-Free Optical Tweezers in the Drosophila Embryo

Published on: November 2, 2018

7.5K

Related Experiment Videos

Last Updated: Jun 18, 2025

Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis
06:33

Probing the Roles of Physical Forces in Early Chick Embryonic Morphogenesis

Published on: June 5, 2018

7.3K
Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo
08:19

Tracking Morphogenetic Tissue Deformations in the Early Chick Embryo

Published on: October 17, 2011

12.9K
Probing Cell Mechanics with Bead-Free Optical Tweezers in the Drosophila Embryo
08:23

Probing Cell Mechanics with Bead-Free Optical Tweezers in the Drosophila Embryo

Published on: November 2, 2018

7.5K

Area of Science:

  • Developmental biology
  • Biophysics
  • Zebrafish embryogenesis

Background:

  • Organ and tissue shape are critical for function.
  • Biochemical signals and biophysical forces influence embryonic morphology.
  • The role of dynamic, tissue-scale forces is often overlooked.

Purpose of the Study:

  • To investigate the contribution of dynamic tissue forces to organ shape.
  • To model and experimentally validate the role of these forces in embryonic development.

Main Methods:

  • Mathematical modeling of tissue dynamics.
  • In vivo experiments using zebrafish embryos.
  • Laser ablation to perturb tissue forces.

Main Results:

  • Model predictions showed dynamic forces driving Kupffer's vesicle shape changes.
  • Laser ablation altered tissue forces, leading to predicted changes in organ shape.
  • These findings highlight the significance of dynamic forces in sculpting embryonic organs.

Conclusions:

  • Dynamic forces generated by tissue movements are a key mechanism for shaping organs during embryogenesis.
  • This study demonstrates the importance of considering tissue-scale forces in developmental biology.