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A Low Mortality Rat Model to Assess Delayed Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage
Published on: January 17, 2013
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Outcomes Measures in Subarachnoid Hemorrhage Research
Elena Sagues1, Andres Gudino1, Carlos Dier1
1Department of Neurology, University of Iowa, 200, Hawkins Drive, Iowa City, IA, USA.
Translational Stroke Research
|July 29, 2024
Summary
Standardized outcome scales are crucial for subarachnoid hemorrhage (SAH) research to effectively evaluate new therapies. This review recommends specific scales for assessing neurological, functional, cognitive, and quality-of-life outcomes in SAH patients.
Area of Science:
- Neurology
- Clinical Research Methodology
Background:
- Subarachnoid hemorrhage (SAH) continues to have high morbidity despite advances in acute care.
- Standardized outcome assessment is essential for evaluating novel therapeutic interventions in SAH research.
Purpose of the Study:
- To provide a comprehensive review of commonly used outcome scales and clinical endpoints in SAH.
- To offer recommendations for the application and prognostic accuracy of these assessment tools.
Main Methods:
- Review of prevalent scales and clinical outcomes utilized in subarachnoid hemorrhage assessment.
- Analysis of recommendations for scale application and prognostic accuracy.
Main Results:
- Standardized terminology for pathophysiological outcomes like symptomatic vasospasm and delayed cerebral ischemia is recommended.
- Clinical severity scales (e.g., World Federation of Neurosurgical Societies, modified Fisher) should be integrated into trials.
- The modified Rankin Scale and Glasgow Outcome Scale-Extended are recommended for functional and broader social/behavioral evaluations, respectively.
- Cognitive and behavioral outcomes, often overlooked, require comprehensive assessment using tools like the Montreal Cognitive Assessment and psychological inventories.
Conclusions:
- Standardized reporting of pathophysiological outcomes and integration of clinical severity scales are advised for SAH research.
- Appropriate selection and application of outcome scales, including those for cognitive, behavioral, and quality-of-life assessments, are crucial for comprehensive SAH patient evaluation.
- Avoiding score dichotomization is vital to preserve valuable patient data and improve prognostic accuracy.
