Related Experiment Video
Updated: Jun 18, 2025
08:57
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
Published on: May 17, 2024
1.9K
Intramuscular mesenchymal chondrosarcoma surrounded by a split fat sign mimicking a benign lesion
Dmitriy Starostin1, Samuel Crompton2, Malee Fernando3
1Radiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK dmitriystarostin871@yahoo.co.uk.
BMJ Case Reports
|July 29, 2024
Summary
Mesenchymal chondrosarcoma (MCS), a rare bone cancer, can present atypically in soft tissue with imaging signs usually associated with benign tumors. This case highlights that the "split-fat sign" on MRI may indicate malignancy, not just benign lesions.
Area of Science:
- Oncology
- Radiology
- Pathology
Background:
- Mesenchymal chondrosarcoma (MCS) is a rare and aggressive malignant tumor with uncertain differentiation, accounting for 2-4% of chondrosarcomas.
- While typically affecting bone, approximately 40% of MCS cases involve somatic soft tissues.
- Peak incidence occurs in the second and third decades, but it can affect any age group.
