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Updated: Jun 18, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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The Atrioventricular Coupling in Heart Failure: Pathophysiological and Therapeutic Aspects

Vito Di Terlizzi1, Roberta Barone1, Nicola Di Nunno1

  • 1Cardiology Unit, University Policlinic Hospital Riuniti, 71122 Foggia, Italy.

Reviews in Cardiovascular Medicine
|July 30, 2024
PubMed

Insights

This review highlights the importance of atrioventricular coupling in heart failure. Understanding this interaction is key to diagnosing and treating various heart conditions effectively.

Area of Science:

  • Cardiology
  • Cardiac Physiology

Background:

  • Historically, heart failure research focused on individual heart chambers.
  • Emerging research emphasizes the critical role of atrioventricular (AV) coupling in cardiac function.

Purpose of the Study:

  • To review the principles of AV function and coupling in the left heart.
  • To explore the impact of disrupted AV coupling on cardiovascular diseases.
  • To discuss diagnostic and therapeutic strategies for AV coupling dysfunction.

Main Methods:

  • Literature review of current research on AV coupling.
  • Analysis of echocardiographic techniques for assessing AV function.
  • Overview of recent pharmacological and device-based therapies.

Main Results:

  • Altered AV coupling significantly impacts global heart performance and contributes to heart failure.
  • Echocardiography provides valuable insights into chamber function and AV synchrony.
  • Novel therapeutic approaches are emerging for managing AV coupling abnormalities.

Conclusions:

  • Atrioventricular coupling is a crucial determinant of cardiac health and a key factor in heart failure.
  • Accurate assessment of AV coupling is essential for effective clinical management.
  • Advances in pharmacotherapy and device therapy offer new hope for patients with AV coupling disorders.

Keywords:
atrial failureatrio-ventricular couplingheart failurestrain imaging

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