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Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized
Xinmin Li1, Junzi Long2, Qian Gao2
1School of Traditional Chinese Medicine, Henan University of Chinese Medicine, 450046 Zhengzhou, Henan, China.
Reviews in Cardiovascular Medicine
|July 30, 2024
Summary
Nattokinase supplementation effectively reduces blood pressure, but its effect on cholesterol is dose-dependent, with low doses showing no lipid-lowering benefits. Further research is needed to clarify dose-response relationships for cardiovascular risk factors.
Area of Science:
- Cardiovascular Health
- Nutritional Biochemistry
- Pharmacology
Background:
- Nattokinase, a fibrinolytic enzyme from fermented soybean, shows potential cardiovascular benefits.
- Clinical evidence on nattokinase's impact on cardiovascular risk factors is varied.
- This study evaluates nattokinase's efficacy in managing cardiovascular health.
Purpose of the Study:
- To assess the cardiovascular efficacy of nattokinase supplementation.
- To analyze the effects of nattokinase on blood pressure, lipid profiles, and glucose levels.
- To investigate potential dose-dependent effects of nattokinase on cardiovascular risk factors.
Main Methods:
- Systematic search of four electronic databases for eligible randomized controlled trials.
- Data extraction and summarization by two independent reviewers.
- Meta-analysis and bias risk assessment using Review Manager 5.4 software.
Main Results:
- Six studies with 546 participants were included; overall quality was high.
- Nattokinase significantly reduced systolic and diastolic blood pressure.
- Low-dose nattokinase negatively impacted total, HDL, and LDL cholesterol; high-dose showed increased total cholesterol but no significant HDL/LDL changes.
- Nattokinase supplementation led to a slight increase in blood glucose; no significant effect on triglycerides was observed.
- No notable adverse events were reported.
Conclusions:
- Nattokinase is an effective adjunctive therapy for hypertension.
- Low-dose nattokinase may not provide significant lipid-lowering effects.
- Further research is required to determine if nattokinase's cardiovascular efficacy is dose-dependent.
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