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Shared Genetic Architecture of Obstructive Sleep Apnea and Neck Pain: A Large-Scale Genome-Wide Association Study
Fangjie Yang1, Dan Zhu2, Renyu Yu3
1Fujian Vocational College of Bioengineering, Fuzhou, Fujian Province, 350007,People's Republic of China.
Journal of Pain Research
|December 8, 2025
Summary
Genetic factors significantly link neck pain and obstructive sleep apnea (OSA). Neck pain increases OSA risk, suggesting pain management is crucial for OSA clinical strategies.
Area of Science:
- Genetics
- Sleep Medicine
- Pain Research
Background:
- Investigating the genetic underpinnings of comorbid neck pain and obstructive sleep apnea (OSA).
- Understanding the intrinsic relationship between neck pain and OSA through genetic analysis.
Purpose of the Study:
- To explore the role of genetic factors in the co-occurrence of neck pain and OSA.
- To provide a deeper understanding of the intrinsic relationship between these two conditions.
Main Methods:
- Genome-Wide Association Studies (GWAS) for OSA (FinnGen) and neck pain (UK Biobank).
- Genetic correlation analysis using LDSC and HDL methods.
- Mendelian randomization (MR), Cross-Phenotype Association (CPASSOC), and Transcriptome-wide association study (TWAS) for causality and mechanism exploration.
Main Results:
- Mendelian randomization indicated that neck pain increases the risk of developing OSA.
- 150 pleiotropic SNPs and 85 pleiotropic genes were identified, implicating neurodevelopmental and metabolic pathways.
- Pleiotropic gene expression was concentrated in brain tissues, particularly the cerebral cortex.
Conclusions:
- Genetic factors play a pivotal role in neck pain-OSA comorbidity.
- Findings support integrating pain management into clinical strategies for OSA treatment.
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