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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Types of RNA01:20

Types of RNA

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

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De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
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Related Experiment Video

Updated: Jun 18, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Noncoding RNAs and Cardiac Fibrosis.

Changyong Wu1, Suli Bao1, Ruijie Li1

  • 1Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, 650000 Kunming, Yunnan, China.

Reviews in Cardiovascular Medicine
|July 30, 2024
PubMed
Summary
This summary is machine-generated.

Myocardial fibrosis, a key factor in heart failure and arrhythmias, lacks effective treatments. Noncoding RNAs are emerging as crucial regulators and potential therapeutic targets for this condition.

Keywords:
biomarkergene regulationmolecular mechanismmyocardial fibrosisnon-coding RNAs

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Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • RNA Biology

Background:

  • Myocardial fibrosis is a hallmark of advanced cardiovascular diseases, contributing to heart failure and arrhythmias.
  • Current treatments for myocardial fibrosis are limited due to incomplete understanding of its molecular underpinnings.
  • Noncoding RNAs play critical roles in cardiac cellular processes and disease development.

Purpose of the Study:

  • To review the intricate relationship between noncoding RNAs and the development of myocardial fibrosis.
  • To highlight the regulatory roles of noncoding RNAs in cardiac fibroblast proliferation and transformation.
  • To explore the potential of noncoding RNAs as biomarkers and therapeutic targets for cardiac fibrosis.

Main Methods:

  • Literature review of studies investigating noncoding RNAs in cardiovascular disease.
  • Analysis of research on noncoding RNA regulation of cardiac fibroblast behavior.
  • Synthesis of current knowledge on noncoding RNAs as therapeutic targets.

Main Results:

  • Noncoding RNAs are significantly involved in cardiomyocyte differentiation, transcription, and apoptosis.
  • Noncoding RNAs modulate cardiac fibroblast proliferation and activation via specific signaling pathways.
  • Evidence suggests noncoding RNAs can serve as predictive biomarkers for cardiac fibrosis.

Conclusions:

  • Noncoding RNAs are critical regulators in the pathogenesis of myocardial fibrosis.
  • Targeting noncoding RNAs offers a promising avenue for novel therapeutic strategies against cardiac fibrosis.
  • Further research into noncoding RNA mechanisms is essential for developing effective fibrosis reversal drugs.