Related Experiment Video

Updated: Jun 18, 2025

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.4K

Hyperuricemia and Gout are Associated with the Risk of Atrial Fibrillation: An Updated Meta-Analysis

Yingjian Deng1, Qiang Li1, Faguang Zhou1

  • 1Department of Cardiology, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, 361000 Xiamen, Fujian, China.

Reviews in Cardiovascular Medicine
|July 30, 2024
PubMed

Insights

High uric acid levels and gout are linked to a greater risk of developing atrial fibrillation (AF). This meta-analysis confirms the association, highlighting the need for further research into this cardiovascular connection.

Area of Science:

  • Cardiology
  • Epidemiology
  • Metabolic Disorders

Background:

  • Hyperuricemia and gout have been suspected as predictors of atrial fibrillation (AF).
  • However, robust epidemiological evidence supporting this association remains limited.

Purpose of the Study:

  • To conduct an updated systematic review and meta-analysis.
  • To rigorously assess the association between hyperuricemia/gout and atrial fibrillation.

Main Methods:

  • A systematic literature search was conducted across EMBASE, PubMed, and Web of Science up to September 2021.
  • Meta-analysis employed random-effects models to determine relative risk (RR) and 95% confidence intervals (CI).
  • Subgroup analyses explored variations by geographic location and study design.

Main Results:

  • Twelve studies were included, with 8 indicating hyperuricemia is associated with increased AF incidence (RR: 1.83).
  • Significant associations were noted in Chinese studies (RR: 1.88) and cross-sectional designs (RR: 2.35).
  • Gout was also linked to an increased AF risk (RR: 1.33).

Conclusions:

  • Hyperuricemia and gout are associated with a higher incidence of atrial fibrillation.
  • These findings underscore the potential cardiovascular implications of elevated uric acid and gout.
Abstract

Keywords:
atrial fibrillationgouthyperuricemiameta-analysissystematic review

More Related Videos

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

83.5K
Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.7K

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.3K
Antihypertensive Drugs: Angiotensin II Receptor Blockers01:30

Antihypertensive Drugs: Angiotensin II Receptor Blockers

In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
674
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
413
Antihypertensive Drugs: Direct Renin Inhibitors01:25

Antihypertensive Drugs: Direct Renin Inhibitors

The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
521