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Research Landscape on Atherosclerotic Cardiovascular Disease and Inflammation: A Bibliometric and Visualized Study
Wende Tian1,2,3, Tai Zhang1,2,4, Xinyi Wang1,2,3
1Xiyuan Hospital, China Academy of Chinese Medical Sciences, 100091 Beijing, China.
Insights
This bibliometric analysis reveals that research on atherosclerotic cardiovascular disease (ASCVD) and inflammation is rapidly advancing. Key themes include NLRP3 inflammasome, gut microbiota, and exosomes, with significant contributions from Asian, European, and North American countries.
Area of Science:
- Cardiovascular Research
- Inflammation Biology
- Bibliometrics
Background:
- Atherosclerotic cardiovascular disease (ASCVD) poses a significant global health challenge.
- Inflammation is increasingly recognized as a key pathological factor in ASCVD.
- Targeting inflammation shows promise for reducing cardiovascular events.
Purpose of the Study:
- To conduct a bibliometric analysis of global research on ASCVD and inflammation.
- To map the research landscape, identify key contributors, and highlight emerging research foci.
Main Methods:
- Bibliometric analysis of 19,053 publications from 2012-2022 (Web of Science Core Collection).
- Visualization of publication trends, country/institution/author collaborations, and keyword co-occurrence using CiteSpace and VOSviewer.
Main Results:
- China led in publications (32.71%), followed by Capital Med Univ as the most productive institution.
- Christian Weber was the most prolific author; PloS one and Circulation were the most prolific and co-cited journals, respectively.
- Hot keywords included NLRP3 inflammasome, intestinal microbiota, exosomes, and lncRNAs.
Conclusions:
- ASCVD and inflammation research is impactful, with dominant contributions from Asia, Europe, and North America.
- Key emerging themes include NLRP3 inflammasome, gut microbiota, autophagy, lncRNAs, and exosomes.
- Bibliometric analysis provides insights into the global research architecture and current trends in this field.
Background:
The atherosclerotic cardiovascular disease (ASCVD) is a major killer and health care burden worldwide. Atherosclerosis, the common pathological foundation, has been associated with inflammation over the past few years. Some promising results also have emerged suggesting the role of targeting inflammation as a potential therapeutic option to reduce cardiovascular events. In light of the pathogenic role that inflammation plays in ASCVD, we propose to evaluate the worldwide research architecture for ASCVD and inflammation using bibliometric analysis.
Methods:
A search of the Web of Science Core Collection of Clarivate Analytics was performed for articles in the field published between 2012 and 2022. The number of publications per year has been visualized using GraphPad Prism through time. CiteSpace and VOSviewer were used to generate knowledge maps about the collaboration of countries, institutions, and authors, and to represent the landscape on ASCVD and inflammation research as well as to reveal current foci.
Results:
There were a total of 19,053 publications examined in this study. The most publications came from China (6232, 32.71%). Capital Med Univ was the most productive institution (410, 2.15%). Christian Weber published the greatest number of articles (75, 0.39%). PloS one was identified as the most prolific journal (706, 3.71%). Circulation was the most co-cited journal (13276, 2.81%). Keywords with the ongoing strong citation bursts were "nucleotide-binding oligomerization (NOD), Leucine-rich repeat (LRR)-containing protein (NLRP3) inflammasome", "intestinal microbiota", "exosome", "lncRNAs", etc.
Conclusions:
It can be shown that ASCVD and inflammation research benefited from manuscripts that had a high impact on the scientific community. Asian, European and North American countries dominated in the field in terms of quantitative, qualitative and collaborative parameters. The NLRP3 inflammasome, gut microbiota and trimethylamine N-oxide, autophagy, lncRNAs, exosomes, and nuclear factor erythroid 2-related factor 2 were described to be hot themes in the field.
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