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Related Experiment Videos

Allograft viability determined by enzyme analysis.

J E Codd, P J Garvin, R Morgan

    Transplantation
    |December 1, 1979
    PubMed
    Summary
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    Serum lactic dehydrogenase (LDH) levels can assess kidney function after ischemia and predict rejection response. However, LDH alone cannot determine therapy withdrawal, as sustained high levels indicate irreversible rejection.

    Area of Science:

    • Nephrology
    • Transplantation Immunology
    • Biochemistry

    Background:

    • Assessing kidney graft viability after ischemia is crucial for patient outcomes.
    • Enzymatic analysis of venous effluent has limitations in predicting kidney function.
    • Postoperative monitoring is essential for managing kidney transplant rejection.

    Purpose of the Study:

    • To evaluate the utility of serum lactic dehydrogenase (LDH) in assessing kidney allograft function post-ischemia.
    • To determine if LDH levels correlate with the response to immunosuppressive therapy during rejection episodes.
    • To establish the role of LDH in guiding therapeutic decisions in kidney transplantation.

    Main Methods:

    • Analysis of enzymatic markers in the venous effluent of ischemically injured kidneys.

    Related Experiment Videos

  • Postoperative serum assays for lactic dehydrogenase (LDH) levels.
  • Correlation of LDH levels with clinical outcomes and response to immunosuppression.

    • Main Results:

    • Enzymatic analysis of venous effluent did not accurately predict the kidney's ability to support life.
    • Postoperative serum LDH levels are valuable in assessing kidney functional status.
    • LDH levels correlate with the response of rejection episodes to immunosuppression.
    • A decline in LDH indicates successful treatment, while failure to normalize suggests irreversible rejection.

    Conclusions:

    • Serum LDH is a valuable biomarker for assessing kidney allograft function and response to immunosuppression.
    • LDH monitoring aids in managing kidney transplant rejection but should not be the sole factor in withholding therapy.
    • Sustained elevated LDH levels post-transplant can indicate irreversible rejection, guiding prognosis and treatment adjustments.