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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
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Related Experiment Video

Updated: Jun 18, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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The circadian rhythm: A key variable in aging?

Patrick R Winterhalter1, Adrian-Iustin Georgevici1,2, Nitin J Gharpure1

  • 1Clinic for Heart Surgery (UMH), Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.

Aging Cell
|July 30, 2024
PubMed
Summary
This summary is machine-generated.

Investigating aging transcriptional changes revealed circadian rhythms (CiR) as key markers. Restoring CiR function may offer therapeutic opportunities for age-related decline and enhance healthspan.

Keywords:
Bhlhe40 (Dec1)aging hallmarkscircadian rhythmsinteraction networkmachine learningmouse cohortorgan strain sexsex hormones

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Area of Science:

  • Genomics and Molecular Biology
  • Aging Research
  • Systems Biology

Background:

  • Understanding age-related transcriptional changes is crucial for health and longevity.
  • Previous studies on aging cohorts faced limitations due to sample size, strain, tissue, and age range biases.
  • Identifying robust aging biomarkers requires comprehensive and broadly applicable methodologies.

Purpose of the Study:

  • To identify common aging features with high general validity across diverse biological contexts.
  • To investigate the role of circadian rhythms (CiR) and proteostasis in the aging process.
  • To explore potential therapeutic targets for age-related diseases.

Main Methods:

  • Bulk RNA sequencing was performed on a mouse cohort encompassing seven organs, two strains, both sexes, and five age points.
  • Machine learning, specifically the Boruta algorithm, was employed for feature selection and identification of aging markers.
  • Network analysis was used to map gene expression profiles and identify key interaction axes, such as the CiR-proteostasis axis.

Main Results:

  • Circadian rhythm (CiR) transcripts emerged as prominent age markers in unsupervised analysis.
  • Four major gene expression profiles were identified, with CiR and proteostasis showing conspicuous, partially opposing changes.
  • Hormonal influences, like sex hormones, were found to modulate CiR transcript expression, impacting senescence regulators.

Conclusions:

  • The bilateral dysregulation of circadian rhythms (CiR) is a fundamental aspect of aging.
  • CiR transcripts show potential as reliable biological markers for aging.
  • Restoration of CiR function presents a promising therapeutic strategy for aging and related conditions.