Related Experiment Video
Updated: Jun 18, 2025
05:56
Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
Published on: June 21, 2024
759
Methadone for Pain Management in Chemotherapy-Induced Peripheral Neuropathy: A Retrospective Review
Christiane Boen1, Julia Ridley2,3, Philippa Hawley2,3
1Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Journal of Pain & Palliative Care Pharmacotherapy
|July 30, 2024
Summary
Methadone may offer effective pain relief for chemotherapy-induced peripheral neuropathy (CIPN). This retrospective study found 65% of patients experienced benefits, suggesting methadone
Area of Science:
- Oncology
- Neurology
- Pharmacology
Background:
- Chemotherapy-Induced Peripheral Neuropathy (CIPN) affects over 30% of cancer patients.
- Limited effective treatments exist, with duloxetine showing only modest efficacy.
- Opioids are used for cancer pain and other neuropathic pain conditions.
Purpose of the Study:
- To evaluate the effectiveness of methadone in managing pain associated with CIPN.
- To explore methadone as a potential alternative for CIPN pain management.
Main Methods:
- Retrospective chart review of 31 patients treated with methadone for CIPN pain.
- Analysis of patient-reported outcomes regarding methadone's effectiveness.
Main Results:
- 65% of patients reported methadone as an effective treatment for CIPN pain.
- 19% found it ineffective, and 16% reported partial or temporary effectiveness.
- Significant variability in patient response to methadone was observed.
Conclusions:
- Methadone demonstrates potential as an analgesic for painful CIPN.
- Advantages include low cost and lack of metabolites for long-term use.
- Further prospective studies are needed to confirm efficacy and safety, considering risks like QT prolongation.
Related Concept Videos
01:29Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists
240
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
Phenothiazines, such as prochlorperazine...
240
01:15Opioid Analgesics: Synthetic and Semisynthetic Opioids
260
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
260
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
208
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
208
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
157
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
157
01:25Analgesia and Pain Management
557
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
557
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
187
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
187