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Updated: Jun 18, 2025
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Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
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Evidence-based use of epinephrine in anaphylaxis.
Catherine Hammond1, Jay Adam Lieberman
1Department of Pediatrics, Division of Pulmonology, Allergy & Immunology, University of Tennessee Health Science Center, LeBonheur Children's Hospital, Memphis, Tennessee, USA.
Current Opinion in Allergy and Clinical Immunology
|July 30, 2024
Summary
Epinephrine remains the primary treatment for anaphylaxis, despite limited supporting data. Recent research enhances understanding of its effects and autoinjector utility.
Area of Science:
- Allergy and Immunology
- Emergency Medicine
- Pharmacology
Background:
- Anaphylaxis is a severe allergic reaction requiring immediate treatment.
- Epinephrine is the established first-line therapy for anaphylaxis.
- Existing data supporting epinephrine's efficacy in anaphylaxis is limited.
Purpose of the Study:
- To review current evidence supporting epinephrine use in anaphylaxis.
- To examine data on epinephrine autoinjector prescription and usage.
- To evaluate newer epinephrine delivery methods, focusing on recent literature.
Main Methods:
- Systematic literature review of recent publications (past few years).
- Analysis of epidemiological studies on anaphylaxis.
- Evaluation of data on epinephrine's pharmacological effects and clinical utility.
Main Results:
- New epidemiologic data and studies on novel epinephrine formulations are emerging.
- Recent findings are improving the understanding of epinephrine's effects in anaphylaxis.
- Shortcomings in epinephrine's real-world effectiveness and practical utility are being identified.
Conclusions:
- Epinephrine is confirmed as the first-line treatment for anaphylaxis.
- A clearer understanding of epinephrine's effects in healthy individuals and during anaphylaxis is developing.
- Ongoing research aims to optimize epinephrine's use and delivery for anaphylaxis management.
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