Related Experiment Video
Updated: Apr 5, 2026
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A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
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Novel Epinephrine Delivery Devices
Nicole O' Malley1, Jay Adam Lieberman1
1Division of Pulmonology, Allergy & Immunology, Department of Pediatrics, University of Tennessee Health Science Center, LeBonheur Children's Hospital, Memphis, TN, USA.
Immunology and Allergy Clinics of North America
|April 3, 2026
Summary
Novel, needle-free epinephrine delivery via intranasal or sublingual routes shows promise for anaphylaxis treatment. These methods offer similar pharmacokinetics to autoinjectors, with intranasal devices now available for prescription.
Area of Science:
- Allergy and Immunology
- Pharmacology
- Emergency Medicine
Background:
- Research is exploring novel, non-injectable epinephrine delivery methods.
- Intranasal and sublingual routes aim for needle-free epinephrine administration.
- These routes seek to achieve pharmacokinetics comparable to traditional autoinjectors.
Purpose of the Study:
- To review recent research on non-injectable epinephrine delivery routes.
- To inform clinicians about needle-free epinephrine options for anaphylaxis.
- To support shared decision-making regarding epinephrine use.
Main Methods:
- Literature review of studies on intranasal and sublingual epinephrine.
- Analysis of pharmacokinetic data comparing non-injectable routes to autoinjectors.
- Inclusion of information on currently available intranasal epinephrine devices.
Main Results:
- Non-injectable routes, including intranasal, can achieve pharmacokinetics similar to autoinjectors.
- An intranasal epinephrine device is now available for prescription for at-risk patients.
- These findings support the viability of needle-free epinephrine options.
Conclusions:
- Clinicians need to be aware of emerging non-injectable epinephrine delivery systems.
- Shared decision-making is crucial for determining the appropriateness of non-injectable epinephrine for patients.
- Non-injectable epinephrine represents a significant advancement in anaphylaxis management.
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