Flavonoids and Gastric Cancer Therapy: From Signaling Pathway to Therapeutic Significance

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Jiaying Cai1, Xiyue Tan2, Qichao Hu2

  • 1School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.

Drug Design, Development and Therapy
|July 31, 2024
PubMed

Insights

Flavonoids show promise in fighting gastric cancer (GC) by inhibiting tumor growth and promoting cell death. Combining these natural compounds with chemotherapy may overcome resistance and improve treatment outcomes.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Gastric cancer (GC) presents significant mortality and recurrence challenges.
  • Current GC treatments face limitations, necessitating novel therapeutic strategies.
  • Flavonoids, natural compounds, are emerging as potential anti-cancer agents.

Purpose of the Study:

  • To review and summarize the anti-tumor mechanisms of flavonoids against gastric cancer.
  • To explore the potential of flavonoids as novel therapeutic agents for GC.
  • To identify synergistic effects of flavonoids with conventional therapies.

Main Methods:

  • Comprehensive literature search of PubMed, Web of Science, and SpringerLink databases.
  • Keywords used: "gastric cancer", "stomach cancers", "flavonoid", "bioflavonoid", "2-Phenyl-Chromene".
  • Analysis and synthesis of identified studies on flavonoid mechanisms in GC treatment.

Main Results:

  • Flavonoids inhibit GC tumor growth, proliferation, invasion, and metastasis.
  • Flavonoids induce cancer cell death via apoptosis, autophagy, ferroptosis, and pyroptosis.
  • Combination therapy with flavonoids and chemotherapeutics (e.g., 5-FU) may reduce chemoresistance.

Conclusions:

  • Flavonoids exhibit multifaceted anti-cancer activities against gastric cancer.
  • Synergistic effects observed when combining flavonoids with chemotherapy or other natural products.
  • Flavonoids offer innovative perspectives for developing new anti-GC drugs.
Keywords:
angiogenesisapoptosisflavonoidgastric cancer

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