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Updated: Jun 18, 2025
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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
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Lipoprotein (a) and cerebrovascular disease.
Constantine E Kosmas1, Maria D Bousvarou2, Evangelia J Papakonstantinou3
12nd Department of Cardiology, National & Kapodistrian University of Athens, Athens, Greece.
The Journal of International Medical Research
|July 31, 2024
Summary
Elevated lipoprotein (a) [Lp(a)] is linked to cerebrovascular events like stroke in adults and children. New Lp(a)-targeting therapies show promise for stroke prevention.
Area of Science:
- Cardiology
- Neurology
- Genetics
Background:
- Lipoprotein (a) [Lp(a)] is structurally similar to LDL cholesterol.
- Lp(a) is synthesized in the liver, with genetically determined plasma levels influenced by the LPA gene encoding apolipoprotein (a).
Purpose of the Study:
- To comprehensively review the role of Lp(a) in cerebrovascular disease.
- To examine the Lp(a)-cerebrovascular disease relationship from multiple perspectives.
Main Methods:
- Narrative review of pertinent studies.
- Analysis of epidemiological and Mendelian randomization data.
- Inclusion of data on pediatric patients and emerging therapies.
Main Results:
- Epidemiological studies show a positive correlation between high Lp(a) levels and cerebrovascular events, particularly ischemic strokes.
- The correlation is noted to be marginal in Mendelian randomization studies.
- Lp(a) appears significant in pediatric arterial ischemic stroke pathogenesis due to the absence of typical risk factors.
Conclusions:
- New Lp(a)-targeting agents are in Phase 3 trials for stroke risk reduction.
- Updated guidelines for Lp(a) screening and management are needed for effective primary and secondary stroke prevention.
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