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Association between dietary protein intake and mortality among patients with diabetic kidney disease
Yichuan Wu1, Jiaqi Chen2, Yuan Tao1
1Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China; De Feng Academy, Southern Medical University, Guangzhou, China.
Aims:
This study aimed to investigate the association between dietary protein intake and mortality among patients with diabetic kidney disease.
Methods:
The research encompassed a total of 2901 participants diagnosed with diabetic kidney disease, drawn from the National Health and Nutrition Examination Survey (NHANES). To determine outcomes related to all-cause and cardiovascular mortality, connections were established with the National Death Index up until December 31, 2019. Estimations of hazard ratios (HRs) and their corresponding 95 % confidence intervals (CIs) were conducted using Cox proportional hazard ratio models.
Results:
During the 261,239 person-years of follow-up, 1236 deaths were recorded. After multivariate adjustment, the weighted hazard ratio (HR) and 95 % CIs for participants with 1.0-1.2 g/kg of protein intake was 0.65 (0.44, 0.96) for all-cause mortality. A higher proportion of animal protein intake was found to be associated with an increased mortality risk. Stratified analyses showed that higher protein intake benefited older participants.
Conclusions:
In diabetic kidney disease patients, 1.0-1.2 g/kg of protein was associated with lower mortality and 0.6-1.2 g/kg of protein especially benefitted patients ≥60 years.
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