Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hijacking radiotherapy-induced chemokines with self-assembled molecular decoys for glioblastoma radio-immunotherapy.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Defining the Incremental Value of Endoscopic Ultrasound in Assessing Pancreatic Cystic Neoplasms.

Annals of surgery·2026
Same author

Carrier-free targeted co-assembly of glycyrrhizin and puerarin overcomes ocular barriers for corneal alkali burn therapy via macrophage reprogramming.

Materials today. Bio·2026
Same author

Screening of Monoclonal Antibodies from Integrated Phage and Mammalian Cell Display Libraries.

Methods in molecular biology (Clifton, N.J.)·2026
Same author

Deeptosis: A Deep Learning-Based Platform for Label-Free Discrimination of Apoptosis and Pyroptosis from Brightfield Microscopy.

Journal of molecular biology·2026
Same author

Spatial metabolomics and transcriptomics reveal the metabolic-immune niche associated with renal fibrosis in hyperuricemia.

Free radical biology & medicine·2026

Related Experiment Video

Updated: Jun 18, 2025

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
07:00

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

Published on: September 26, 2016

16.3K

Nanomaterials for bone metastasis.

Xinyan Hao1, Buchan Jiang2, Junyong Wu3

  • 1Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Xiangya School of Medicine, Central South University, Changsha, Hunan 410011, China; Department of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|July 31, 2024
PubMed
Summary
This summary is machine-generated.

Nanotechnology offers new hope for treating bone metastases, which are common in cancer. Intelligent nanosystems can regenerate bone and blood vessels, eliminate tumor cells, and improve healing, addressing limitations of current therapies.

Keywords:
Bone metastasisBone microenvironmentDrug deliveryNanomaterialsNanosystems

More Related Videos

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

351
Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
10:01

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

6.4K

Related Experiment Videos

Last Updated: Jun 18, 2025

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
07:00

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

Published on: September 26, 2016

16.3K
Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

351
Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
10:01

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

6.4K

Area of Science:

  • Oncology
  • Biotechnology
  • Nanomedicine

Background:

  • Bone metastasis is a frequent and serious complication of primary malignant tumors, significantly worsening patient prognosis.
  • The bone microenvironment, a complex interplay of various cell types, is crucial for the development and progression of bone metastases.
  • Current therapeutic strategies for bone metastases are limited, necessitating novel treatment approaches.

Purpose of the Study:

  • To review the mechanisms and current clinical therapies for bone metastases.
  • To highlight the advancements and potential of intelligent nanosystems in managing bone metastases.
  • To explore the role of nanoplatforms in theranostics for bone metastases.

Main Methods:

  • Comprehensive review of existing literature on bone metastasis mechanisms and therapies.
  • Analysis of the application of nanotechnology, specifically nanoplatforms, in bone metastasis treatment.
  • Discussion of intelligent nanosystems designed for vascular and bone regeneration, tumor elimination, and bone healing.

Main Results:

  • Nanotechnology, owing to the unique properties of nanoplatforms, presents a promising avenue for the management and prevention of bone metastases.
  • Intelligent nanosystems demonstrate multifaceted capabilities including stimulating vascular and bone regeneration, eliminating tumor cells, and accelerating bone healing.
  • Bone-targeting nanoplatforms offer innovative theranostic strategies for bone metastases.

Conclusions:

  • Nanotechnology-based approaches, particularly intelligent nanosystems and bone-targeting nanoplatforms, represent a significant advancement in addressing the challenges posed by bone metastases.
  • These innovations hold the potential to improve therapeutic outcomes by promoting regeneration, eradicating tumor cells, and minimizing bone damage.
  • Further development in this area could revolutionize the theranostics of bone metastases.