Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

1.0K
Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biomarkers, surrogates, and evaluation of therapeutic agents: a proposed solution.

Coronary artery disease·1999
Same author

The potential influence of insulin and plasminogen activator inhibitor type 1 on the formation of vulnerable atherosclerotic plaques associated with type 2 diabetes.

Proceedings of the Association of American Physicians·1999
Same author

Differences between activation thresholds for platelet P-selectin glycoprotein IIb-IIIa expression and their clinical implications.

Thrombosis research·1999
Same author

Insulin resistance and thrombosis: a cardiologist's view.

The American journal of cardiology·1999
Same author

TNF-alpha and insulin, alone and synergistically, induce plasminogen activator inhibitor-1 expression in adipocytes.

The American journal of physiology·1999
Same author

Cardiovascular consequences of polycystic ovary syndrome.

Endocrinology and metabolism clinics of North America·1999

Related Experiment Video

Updated: May 6, 2026

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 10, 2010

25.4K

A relationship between ultrasonic integrated backscatter and myocardial contractile function.

S A Wickline, L J Thomas, J G Miller

    The Journal of Clinical Investigation
    |December 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    The cardiac cycle causes changes in ultrasound backscatter, likely due to variations in myocardial elasticity and acoustic impedance at the cellular level. A mechanical model predicts these integrated backscatter (IB) changes during systole.

    More Related Videos

    Ultrasonic Assessment of Myocardial Microstructure
    10:53

    Ultrasonic Assessment of Myocardial Microstructure

    Published on: January 14, 2014

    5.1K
    Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
    12:54

    Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

    Published on: October 2, 2021

    4.0K

    Related Experiment Videos

    Last Updated: May 6, 2026

    High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
    11:50

    High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

    Published on: July 10, 2010

    25.4K
    Ultrasonic Assessment of Myocardial Microstructure
    10:53

    Ultrasonic Assessment of Myocardial Microstructure

    Published on: January 14, 2014

    5.1K
    Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
    12:54

    Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

    Published on: October 2, 2021

    4.0K

    Area of Science:

    • Biomedical Ultrasound
    • Cardiac Mechanics
    • Biophysics

    Background:

    • Physiologic cardiac cycles exhibit variations in integrated backscatter (IB).
    • The underlying mechanisms linking cardiac mechanics to IB variations remain unclear.
    • Understanding these mechanisms is crucial for interpreting ultrasound data in cardiology.

    Purpose of the Study:

    • To investigate the mechanisms responsible for cardiac cycle-dependent variations in myocardial integrated backscatter (IB).
    • To explore the relationship between myocardial contractile function, elastic properties, and acoustic impedance.
    • To develop and validate a mechanical model predicting IB changes during the cardiac cycle.

    Main Methods:

    • Mathematical modeling of cardiac cell mechanics using a three-component Maxwell model.
    • Analysis of acoustic impedance mismatch based on myofibrillar elastic parameters.
    • Experimental validation through passive left ventricular distention to assess regional and global backscatter changes.

    Main Results:

    • The study suggests cyclic alterations in myofibrillar elastic parameters and acoustic impedance mismatch drive IB variations.
    • A three-component Maxwell model successfully predicted the observed systolic decrease in IB.
    • The model also accounted for regional intramural differences and the dependence of IB on global contractile function.

    Conclusions:

    • Cardiac cycle-dependent changes in myocardial acoustic impedance mismatch, influenced by non-Hookian elastic behavior, explain variations in ultrasound integrated backscatter.
    • The proposed mechanical model provides a framework for understanding the link between cardiac mechanics and ultrasound signal.
    • This research offers insights into the biophysical basis of ultrasound imaging in assessing cardiac function.