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Increased Body Temperature

Increased Body Temperature

A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...

Homeostatic Imbalances in Body Temperature

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...

Types of Fever

Types of Fever

Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:

Methods of reducing fever

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:

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Related Experiment Video

Updated: Jun 18, 2025

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

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Fatal hyperpyrexia caused by xylazine: a case report.

Ping Dai¹, Yanqing Chen², Xianqin Luo³

¹Department of Poisoning and Occupational Diseases, Emergency Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Frontiers in Pharmacology

|August 1, 2024

Summary

Xylazine, a veterinary drug, is increasingly found in illicit substances. This case report highlights a fatal xylazine poisoning that caused hyperthermia, a previously undocumented effect in humans.

Keywords:

drugs human hyperpyrexia poisoning xylazine

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Protocol for Long Duration Whole Body Hyperthermia in Mice

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Published on: August 25, 2012

Area of Science:

Veterinary Pharmacology
Toxicology
Human Medicine

Background:

Xylazine is a widely used veterinary sedative, analgesic, and muscle relaxant.
Recent years have seen a significant increase in the detection of xylazine in illicit drug supplies.
Xylazine intoxication is typically associated with central nervous and cardiovascular system depression.

Observation:

A case study involving a 41-year-old male patient with xylazine poisoning is presented.
The patient exhibited severe central nervous and cardiovascular system depression.
Notably, the patient developed hyperpyrexia (dangerously high body temperature) during treatment.

Findings:

This case suggests that xylazine may induce hyperthermia in humans, an effect not previously documented.
The patient's hyperthermia contributed to his death three days post-intoxication.

Implications:

The findings expand the known spectrum of xylazine's adverse effects in humans.
Clinicians should be aware of the potential for xylazine to cause hyperthermia in overdose cases.
This highlights the critical need for monitoring body temperature in patients with xylazine poisoning.