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Updated: Jun 18, 2025
06:38
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
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Immunotherapies and Renal Injury
1Renal Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Current Opinion in Toxicology
|August 1, 2024
Summary
Cancer immunotherapies harness the immune system to fight tumors but can harm kidneys. Early detection and management of immunotherapy-associated kidney injury are crucial for patient outcomes.
Area of Science:
- Oncology
- Immunology
- Nephrology
Background:
- Cancer immunotherapy has revolutionized cancer treatment.
- Effective anti-tumor immunity relies on T-cell activation.
- Immune suppression hinders cancer cell clearance, promoting tumor growth.
Purpose of the Study:
- To highlight the critical role of immunotherapy in cancer treatment.
- To discuss the potential for immunotherapy to cause kidney injury.
- To emphasize the importance of managing immunotherapy-associated kidney injury.
Main Methods:
- Review of current understanding of cancer immunotherapy mechanisms.
- Analysis of clinical outcomes related to immune checkpoint inhibitors and CAR T-cell therapy.
- Examination of the pathophysiology of immunotherapy-induced kidney injury.
Main Results:
- Immunotherapies, including immune checkpoint inhibitors and CAR T-cell therapies, show significant clinical success.
- These therapies can lead to multiorgan dysfunction, notably acute kidney injury.
- Prompt recognition and management are key to preserving kidney function.
Conclusions:
- Cancer immunotherapy offers a powerful approach to treating malignant diseases.
- Awareness and proactive management of kidney injury are essential for optimizing patient care and outcomes in cancer immunotherapy.
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